Detalhe da pesquisa
1.
Identification of inhibitors for the transmembrane Trypanosoma cruzi eIF2α kinase relevant for parasite proliferation.
J Biol Chem
; 299(7): 104857, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37230387
2.
Cyclophilin 19 secreted in the host cell cytosol by Trypanosoma cruzi promotes ROS production required for parasite growth.
Cell Microbiol
; 23(4): e13295, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33222354
3.
The translational challenge in Chagas disease drug development.
Mem Inst Oswaldo Cruz
; 117: e200501, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35613156
4.
EIF2α phosphorylation is regulated in intracellular amastigotes for the generation of infective Trypanosoma cruzi trypomastigote forms.
Cell Microbiol
; 22(11): e13243, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32597009
5.
Effect of lysine acetylation on the regulation of Trypanosoma brucei glycosomal aldolase activity.
Biochem J
; 477(9): 1733-1744, 2020 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32329788
6.
Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes.
Int J Mol Sci
; 21(10)2020 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32455951
7.
Comparative transcriptome profiling of virulent and non-virulent Trypanosoma cruzi underlines the role of surface proteins during infection.
PLoS Pathog
; 13(12): e1006767, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29240831
8.
Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins.
Molecules
; 24(7)2019 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30987092
9.
Comparative Proteomic Analysis of Lysine Acetylation in Trypanosomes.
J Proteome Res
; 17(1): 374-385, 2018 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29168382
10.
Overexpression of eukaryotic initiation factor 5A (eIF5A) affects susceptibility to benznidazole in Trypanosoma cruzi populations.
Mem Inst Oswaldo Cruz
; 113(9): e180162, 2018 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30066751
11.
A membrane-bound eIF2 alpha kinase located in endosomes is regulated by heme and controls differentiation and ROS levels in Trypanosoma cruzi.
PLoS Pathog
; 11(2): e1004618, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25658109
12.
Catalase expression impairs oxidative stress-mediated signalling in Trypanosoma cruzi.
Parasitology
; 144(11): 1498-1510, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28653592
13.
Chromatin Proteomics Reveals Variable Histone Modifications during the Life Cycle of Trypanosoma cruzi.
J Proteome Res
; 15(6): 2039-51, 2016 06 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27108550
14.
Reduction of Tubulin Expression in Angomonas deanei by RNAi Modifies the Ultrastructure of the Trypanosomatid Protozoan and Impairs Division of Its Endosymbiotic Bacterium.
J Eukaryot Microbiol
; 63(6): 794-803, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27194398
15.
Characterization of two different Asf1 histone chaperones with distinct cellular localizations and functions in Trypanosoma brucei.
Nucleic Acids Res
; 42(5): 2906-18, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24322299
16.
Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease.
Antimicrob Agents Chemother
; 59(8): 4669-79, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26014945
17.
Click chemistry oligomerisation of azido-alkyne-functionalised galactose accesses triazole-linked linear oligomers and macrocycles that inhibit Trypanosoma cruzi macrophage invasion.
Tetrahedron
; 71(39): 7344-7353, 2015 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-26435551
18.
Stress induces changes in the phosphorylation of Trypanosoma cruzi RNA polymerase II, affecting its association with chromatin and RNA processing.
Eukaryot Cell
; 13(7): 855-65, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24813189
19.
Secreted trypanosome cyclophilin inactivates lytic insect defense peptides and induces parasite calcineurin activation and infectivity.
J Biol Chem
; 288(12): 8772-8784, 2013 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23386612
20.
Specialising the parasite nucleus: Pores, lamins, chromatin, and diversity.
PLoS Pathog
; 13(3): e1006170, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28253370